Journal of Agricultural Science and Engineering
Articles Information
Journal of Agricultural Science and Engineering, Vol.7, No.4, Dec. 2021, Pub. Date: Nov. 22, 2021
N-Benzylated Alkamides Isolated from Maca Planted in China
Pages: 75-86 Views: 878 Downloads: 145
Authors
[01] Jing Gan, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China; Jiangsu Hope-pharm Co., Ltd, Changzhou, P. R. China.
[02] Chuan He, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China.
[03] Qiulu Chen, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China.
[04] Yalin Liu, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China.
[05] Hang Hu, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China.
[06] Xiaoqiang Sun, Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, P. R. China.
[07] Defeng Xu, National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou, P. R. China; Jiangsu Hope-pharm Co., Ltd, Changzhou, P. R. China.
Abstract
Lepidium meyenii (maca) is an edible herbaceous biennial plant of the Brassicaceae family that is native to South America and has been marketed for its traditional medicinal effects. N-benzylated alkamides, commonly known as “macamides”, have been found in maca and are considered as functional component of maca. Macamides could significantly enhance the libido and sexual potency of normal mice, improve anti-fatigue and anti-oxidant status in rats, and function as fatty acid amide hydrolase inhibitors to provide analgesic, anti-inflammatory, and neuroprotective effects. Maca was introduced into China in 2002. Now, China has become an important producer of maca in the world. However, chemical investigations of maca planted in China were rarely reported. Here, seventeen N-benzylated alkamides (macamides) in maca from Wenbi Mountain were identified by liquid chromatography mass spectrometry (LC-MS) and four of them were successfully isolated, namely N-3-methoxybenzyl-9Z-octadecenamide (1), N-benzyl-9Z-octadecenamide (2), N-(3-methoxybenzyl)-hexadecanamide (3), and N-benzyl-hexadecanamide (4). The chemical structure of these four compounds were established by spectroscopic and spectrometric methods including 1H nuclear magnetic resonance (NMR), 13C NMR, 2D NMR, electrospray ionization-high resolution mass spectrometry (ESI-HRMS), ultraviolet–visible spectroscopy (UV-Vis), and fourier transform infrared spectroscopy (FT-IR). These compounds are useful marker compounds for the quality control of Lepidium meyenii planted in China.
Keywords
Maca, Lepidium meyenii, N-benzylated Alkamides, Macamides, Isolation
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