International Journal of Life Science and Engineering
Articles Information
International Journal of Life Science and Engineering, Vol.1, No.2, May 2015, Pub. Date: May 14, 2015
Sero-Prevalence Survey of Rubella IgM Antibodies among Pregnant Women in Kano, Nigeria
Pages: 56-60 Views: 4428 Downloads: 1314
Authors
[01] Yahaya H., Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria.
[02] Ibrahim A., Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria.
[03] Muhammad A. B., Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria.
[04] Dandawaki S. M., Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria.
Abstract
Rubella is a generally mild illness and its serious complications are rare. Although a major section of pregnant women are immune, cases of rubella infection occur in Nigeria among pregnant women. This study was aimed at assessing the prevalence of rubella virus IgM antibody among obstetric population between 15 – 44 age group attending Antenatal Clinic Bamalli Nuhu Maternity Hospital, Kano. The samples were analyses using Enzyme-Linked Immunosorbent Assay technique. A well-structured questionnaire was administered to the subjects to obtain socio-demographic data. Of the total 89 samples screened, 7 (7.87%) were reactive to rubella IgM antigens from the coated wells. Out of 7 positive samples, 4 (4.49%) were within 15–24 years age group, representing the most susceptible group, while the infection rate was lowest among 35–44 age group with prevalence rate of 1 (1.12%). Furthermore, women in the third trimesters of pregnancy were recorded to have the highest prevalence rate to the antibody 3(3.37%) while those at first and second trimesters recorded 1(1.12%) and 2(2.25%) respectively. In addition, no case was recorded among women with higher educational background recorded as compared to those who did not acquire western education with prevalence of 4(4.49%). Finally, it was found that rubella infection still occurs in this population, although the prevalence was slightly low, but burden remain alarming due to poor awareness and the ravage of the disease to the foetuses.
Keywords
IgM, Rubella, Immunosorbent, Bamalli, Obstetric
References
[01] Agbede, O.O., Adeyemi, O.O., Olatinwo, A.W.O., Salisu, T.J. Kolawole, O.M. (2011). Sero-Prevalence of Antenatal Rubella in University of Ibadan Teaching Hospital. The Open Public Health Journal, 4:10-16.
[02] Atreya, C.D., Mohan, K.V. and Kulkarni, S. (2004). Rubella Virus and Birth Defects: Molecular insights into the viral teratogenesis at the cellular level, 70 (7):431-7.
[03] Bamgboye, A.E., Afolabi, K.A., Esumeh, F.I. and Enweani, I.B. (2004). Prevalence of rubella antibody in pregnant women in Ibadan, Nigeria. West Africa Journal of Medicine; 23:245-8.
[04] Barbara, J.H., Sally, J.R., Alice, S.W. and Richard, C.T. (1987). Rubella Virus: Clinical and Pathogenic Microbiology. pp. 811-815.
[05] Cutts, R.F., Robertson, S.E. and Diaz-Ortega, J.L. (2000). Control of rubella syndrome in developing countries, part 1: Burden of disease from CRS. Bull World Health Organization, 75:55-80.
[06] Dayan, G.H., Castillo-Sorzano, p. And Nava, M. (2000). Efforts at rubella elimination in the USA. The impact of hemisphere of virus rubella control. Clinical Infectious Disease, 43:S158-163.
[07] De Santis, M., Cavallere, A.F., Straface, G. and Caruso, A. (2006). Rubella infection in Pregnancy, Reproductive toxicology, 21(4):390-398.
[08] Dykewicz, C.A., Kruszon-Moran D. and McQuillan G.M. (2001). Rubella Seropositivity in the United State, Clinical Infectious Diseases, 33:1279-1286.
[09] Forbi, J.C., Pennap, G., Amauche, G., Sjoge H. and Gabadi, S. (2009). Serologic Survey of Specific Rubella Virus IgM in the sera of Pregnant Women in Makurdi, Benue State. Nigeria (Afr.) Report Health: 13(2): 69-73).
[10] Frank, F. and David, O.W. (1999). Rubella: MedicalVirology. 2nd (ed) 439-48.
[11] Herrmann, K.L. (1985). Rubella virus, manual of Clinical Microbiology. American Society for Microbiology, 4:779-784.
[12] Kenneth, J.R, and George, C.R. (2004). Sherris Medical Microbiology 4th edition. Page 518.
[13] Koki, Y.A., Taura, D.W., Mukhtar, M.D., Musa, M.A., Adamu, S. and Muhammad B.B. (2014). Sero-Prevalence of Rubella Virus IgM Antibodies among Pregnant Women Attending Muhammadu Abdullahi Wase Specialist Hospital Kano. Communications in Applied Sciences, 2:1.
[14] Lee, J.Y. and Bowden, D.S. (2000). Rubella virus replication and links to teratogenicity. Clinical Microbiology Reviews, 13(4):571-587.
[15] Miller, E., Cradock-Watson, J.E. and Pollock, T.M. (2000). Consequences of confirmed maternal rubella at successive stages of pregnancy. Lancet, 2:781-4.
[16] Neighbors, M. and Tannnell-Jones, R. (2010). Childhood disease and disorders. Cengage Learning, Pp 457-79.
[17] Ogbonnaya, E.C., Eleazu, K., Chinedum, A. J. and Esther, A. (2012). Survey of the sero-prevalence of IgM antibodies in pregnant women infected with Rubella virus.Journal of Biotechnology and Pharmaceutical Research, 3(1):10-14.
[18] Reddy, M., Bindu, H.L., Reddy, P.P. and Rani, U.P. (2006). Role of intrauterine Rubella infection in the causation of congenital deafness, Indian Journal of Human Genetic. 12:140-3.
[19] Richardson, M., Elliman, D., Maguine, H., Simpson, J. and Nicoll, A. (2001). Evidence base of incubation periods of Infectiousness and exclusion policies for the control of communicable disease in schools and preschools. Journal of Paediatrics Infectious Disease, 20(4):380-91.
[20] Usher, A., Shashi, C., and Aruna, A., (2004). Prevalence of IgM Antibodies to Toxoplasma, Rubella and Cytomegalovirus Infections during Pregnancy. JK Science; 6(4): 190 – 2.
[21] World Health Organization (2007). Manuals for the laboratory diagnosis of measles and rubella virus infection. 2nd ed. Geneva, Switzerland.
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